Peptide monographs
25 per-peptide evidence summaries. Each carries an A–X evidence grade, human-data status, UK approval status, regulatory-sensitivity flag, and mechanism category. Filter and sort to find what you need.
For combination evidence reviews see the stack evidence reviews directory. To understand how grades are assigned, see the A–X evidence-grading methodology. For UK regulatory context for the class as a whole, see the UK regulation hub.
AOD-9604 — Growth Hormone C-terminal Lipolytic Fragment
Grade Caka GH-(176-191), Anti-Obesity Drug 9604
AOD-9604 is a stabilised C-terminal fragment of human growth hormone that drives lipolysis without activating the GH receptor or raising IGF-1 levels.
Human data: no·Reg sensitivity: moderateBPC-157 — Body Protection Compound 157
Grade Caka Body Protection Compound 157, PL 14736
BPC-157 is a synthetic pentadecapeptide derived from human gastric juice, researched for tissue repair, gut protection, and angiogenic signalling.
Human data: no·Reg sensitivity: moderateCerebrolysin — Porcine-Brain Neuropeptide Preparation
Grade Baka FPF-1070, EVER Pharma Cerebrolysin
Cerebrolysin is a porcine-brain peptide hydrolysate approved in 40+ countries for post-stroke and cognitive rehabilitation, mimicking NGF and BDNF neurotrophic activity.
Human data: limited·Reg sensitivity: highCJC-1295 — GHRH(1-29) Analogue (no DAC / DAC variants)
Grade Baka DAC:GRF, Mod GRF 1-29 (no-DAC variant)
Research profile of CJC-1295 (no-DAC and DAC variants): GHRH receptor mechanism, pulse biology, dosing protocols, UK regulatory status and reconstitution.
Human data: limited·Reg sensitivity: moderateDSIP — Delta Sleep-Inducing Peptide
Grade Baka Delta Sleep-Inducing Peptide
DSIP is a neuropeptide that promotes delta-wave sleep, suppresses cortisol, and shows promise for insomnia and alcohol withdrawal without dependence risk.
Human data: limited·Reg sensitivity: moderateEpitalon — Pineal Tetrapeptide Bioregulator
Grade Baka Epithalon, Epithalamin (parent extract)
Epitalon (AEDG) is a synthetic tetrapeptide derived from the pineal gland, studied for telomerase activation, melatonin normalisation, and longevity biomarkers.
Human data: limited·Reg sensitivity: moderateGHK-Cu — Copper Tripeptide-1
Grade Caka Copper tripeptide-1, Glycyl-L-Histidyl-L-Lysine Copper
GHK-Cu is a naturally occurring copper-binding tripeptide with robust research backing for skin repair, hair growth, and anti-fibrotic activity via lysyl oxidase and gene modulation.
Human data: no·Reg sensitivity: moderateHumanin — Mitochondrial-Derived 24-Amino-Acid Peptide
Grade Caka HNG, HN
Humanin is a 24-amino-acid mitochondrial peptide with documented neuroprotective, cardioprotective, and insulin-sensitising effects in preclinical research.
Human data: no·Reg sensitivity: moderateIpamorelin — Selective Growth Hormone Secretagogue
Grade Baka NNC 26-0161
Ipamorelin is a selective pentapeptide GHRP that stimulates pulsatile GH release without raising cortisol, prolactin, or ACTH — ideal for research.
Human data: limited·Reg sensitivity: moderateKisspeptin-10 — GnRH-Axis Hypothalamic Decapeptide
Grade Baka KISS1 decapeptide, Metastin (45-54)
Kisspeptin-10 (Kp-10) is the active C-terminal decapeptide of KISS1 that binds GPR54/KISS1R to trigger hypothalamic GnRH pulses and downstream LH/FSH release.
Human data: limited·Reg sensitivity: moderateKPV — α-MSH(11-13) C-Terminal Anti-Inflammatory Tripeptide
Grade Caka Lysine-Proline-Valine, α-MSH C-terminal tripeptide
KPV is the C-terminal tripeptide of α-MSH with oral bioavailability via PepT1 and potent NF-κB-mediated anti-inflammatory activity in gut and skin research models.
Human data: no·Reg sensitivity: moderateLL-37 — Human Cathelicidin Antimicrobial Peptide
Grade Caka Cathelicidin, CAMP
LL-37 is the only human cathelicidin, combining direct antimicrobial membrane disruption with broad immunomodulatory and wound-healing signalling via FPR2/ALX.
Human data: no·Reg sensitivity: moderateMelanotan II — Broad-Spectrum α-MSH Analogue
Grade Baka MT-II, MT2
Melanotan II is a cyclic α-MSH analogue with broad melanocortin agonism across MC1R, MC3R, MC4R, and MC5R, studied for pigmentation and sexual behaviour.
Human data: limited·Reg sensitivity: highMOTS-c — Mitochondrial Open Reading Frame 12S rRNA-c
Grade Caka Mitochondrial-derived peptide, mtDNA-encoded MOTS-c
MOTS-c is a mitochondrial-derived peptide that activates AMPK, mimics exercise-induced gene expression, and declines with age — linking metabolic fitness to mitochondrial output.
Human data: no·Reg sensitivity: moderatePinealon — Pineal Tripeptide Bioregulator
Grade Baka Glu-Asp-Arg, EDR
Pinealon (Glu-Asp-Arg) is a Khavinson tripeptide bioregulator studied for neuroprotection, pineal modulation, and age-related cognitive decline in animal models.
Human data: limited·Reg sensitivity: moderatePT-141 (Bremelanotide) — MC4R-Selective Melanocortin Agonist
Grade Baka Bremelanotide, Vyleesi
PT-141 (Bremelanotide) is an MC4R-selective melanocortin agonist FDA-approved as Vyleesi for premenopausal HSDD, acting centrally to modulate sexual arousal.
Human data: yes·Reg sensitivity: highRetatrutide — Triple GIP/GLP-1/Glucagon Receptor Agonist
Grade Baka LY3437943
Retatrutide (LY3437943) is a once-weekly triple GIP/GLP-1/glucagon receptor agonist in Phase III, showing ~24% mean weight loss in Phase II at 48 weeks.
Human data: yes·Reg sensitivity: highSelank — Tuftsin-Derivative Anxiolytic Heptapeptide
Grade Baka TP-7, Thr-Lys-Pro-Arg-Pro-Gly-Pro
Selank is a synthetic heptapeptide derived from the immunopeptide tuftsin that produces anxiolytic and nootropic effects via GABAergic modulation without benzodiazepine-type dependence.
Human data: limited·Reg sensitivity: moderateSemax — ACTH(4-10) Heptapeptide Nootropic
Grade Baka Met-Glu-His-Phe-Pro-Gly-Pro, MEHFPGP
Semax is a synthetic heptapeptide derived from ACTH(4-10) that upregulates BDNF and NGF, enhancing cognition via intranasal delivery without corticotropic side effects.
Human data: limited·Reg sensitivity: moderateSS-31 (Elamipretide) — Cardiolipin-Targeted Mitochondrial Peptide
Grade Caka Elamipretide, Bendavia
SS-31 (Elamipretide) is a D-amino-acid tetrapeptide that binds cardiolipin in the inner mitochondrial membrane, stabilising the electron transport chain and reducing pathological ROS.
Human data: no·Reg sensitivity: moderateTB-500 — Thymosin β-4 (1-4) Synthetic Fragment
Grade Caka Thymosin β-4 fragment, TB4-fragment
TB-500 is a synthetic 7-amino-acid fragment of Thymosin β-4 researched for tissue repair, angiogenesis, and inflammation modulation via G-actin sequestration.
Human data: no·Reg sensitivity: moderateTesamorelin — Stabilised GHRH Analogue (EGRIFTA)
Grade Baka EGRIFTA, TH9507
Tesamorelin (EGRIFTA) is the only FDA-approved GHRH analogue, clinically validated to reduce visceral adipose tissue in HIV-associated lipodystrophy.
Human data: yes·Reg sensitivity: highThymalin — Thymic Peptide Complex Bioregulator
Grade Baka Thymulin (distinct compound), Thymic peptide preparation (Khavinson)
Thymalin is a Khavinson-developed bovine thymic peptide complex supporting T-cell maturation and cytokine balance, studied in human immunosenescence cohorts for more than fifteen years.
Human data: limited·Reg sensitivity: moderateThymosin α-1 — Thymic Immunomodulatory Peptide (Zadaxin / Thymalfasin)
Grade Baka Tα1, Zadaxin
Thymosin α-1 (Zadaxin/Thymalfasin) is a 28-amino-acid thymic peptide that activates TLR-9 dendritic cells, induces IL-12, and is approved in 30+ countries for hepatitis B and C.
Human data: limited·Reg sensitivity: highTirzepatide — Dual GIP/GLP-1 Receptor Agonist (Mounjaro / Zepbound)
Grade Aaka LY3298176, Mounjaro
Tirzepatide is a once-weekly dual GIP/GLP-1 receptor agonist licensed as Mounjaro (UK/EU) and Zepbound (US) producing ~21% mean weight reduction in SURMOUNT-1.
Human data: yes·Reg sensitivity: high