Research summaries
Plain-English synthesis of the published peptide combination literature, regulatory updates and notes from the laboratory.
2026-05-21
Triple Incretin Agonism — Retatrutide and the GLP-1 / GIP / Glucagon Evidence Base
Critical research-literacy review of the GLP-1 / GIP / glucagon triple-agonist class — receptor pharmacology, Phase II trial evidence for retatrutide, comparison with tirzepatide, and the UK regulatory framing.
2026-05-21
Peptide Stacking Fundamentals — What 'Stack' Means in the Research Literature
An evidence-literacy introduction to what peptide stacking means in published research, when combination evidence is direct vs inferred, and how to read a stack page on PeptideStacks responsibly.
2026-05-21
BPC-157 + TB-500 — A Critical Review of the Combination Evidence
Critical review of the published in vitro and animal-model studies examining BPC-157 and TB-500 together — what the literature shows, what it doesn't, and where the replication gaps sit.
2026-05-21
UK Peptide Regulation 2026 — MHRA Position, POM Class, and Where the Lines Sit
Where UK peptide regulation stands in 2026. The MHRA framework, the GLP-1 / POM reclassification picture, the borderline-product test, and the compounds attracting active enforcement.
2026-05-15
Reading a Peptide Research Study — A Glossary of Terms
How to interpret peptide research papers — methodology terms, study design language, and what 'translational potential' actually means.
2026-05-13
Why Animal-Model Peptide Studies Don't Translate to Human Outcomes
Most peptide research is rodent — what limits extrapolation to human pharmacokinetics, pharmacodynamics and clinical effect.
2026-05-10
The Sikiric Lab Body of Work on BPC-157 — A Citation Map
Predrag Sikiric's 30+ year research program on BPC-157 — what each major paper established, organised by tissue system.
2026-05-08
GLP-1 Receptor Biology Explained — From Exendin to Retatrutide
The evolution of the incretin class — GLP-1 alone, dual GIP/GLP-1 (Tirzepatide), to triple GIP/GLP-1/glucagon (Retatrutide). Mechanism and the rationale for adding receptors.
2026-05-05
Khavinson Bioregulators — The Soviet Peptide Tradition
Vladimir Khavinson's four-decade research program on short peptide bioregulators — Epitalon, Thymalin, Cortexin, Pinealon. Methodology and lifespan extension claims.
2026-04-30
MHRA vs FDA vs EMA — Peptide Regulatory Comparison 2026
How the UK MHRA, US FDA and EU EMA each classify and regulate research-grade peptides in 2026. Approval pathways, enforcement priorities, import rules.