Semax + Selank + Pinealon Nootropic Stack
Russian-origin neuropeptide nootropic research stack — BDNF up-regulation, anxiolytic action and pineal cognition support. Full intranasal research protocol.
Both Semax and Selank are heptapeptide derivatives of endogenous human neuropeptides (ACTH(4-10) and tuftsin respectively), developed in the late Soviet era and widely studied in Russian preclinical and Phase I/II literature. Pinealon adds a pineal-peptide cognitive support layer.
Mechanism of action
Semax — mechanism of action
Synthetic heptapeptide derivative of ACTH(4–10), lacking corticotropic activity. In research:
- Up-regulates BDNF and NGF in hippocampus and cortex.
- Increases dopaminergic and serotonergic tone in rodent prefrontal cortex.
- Documented neuroprotective effects in ischaemic stroke models.
- Approved as a Russian-Federation prescription nootropic; outside Russia it is an unapproved research compound.
Selank — mechanism of action
Synthetic heptapeptide derivative of tuftsin. In published research:
- Anxiolytic via GABAergic modulation without sedation or dependence.
- Up-regulates serotonin metabolism in hippocampus.
- Modulates expression of GABA-A receptor subunits.
Pinealon — mechanism of action
Synthetic tripeptide (Glu-Asp-Arg) developed by the Khavinson group as a pineal-gland-targeted cognition support compound. In animal models:
- Crosses the blood-brain barrier with documented neuroprotective effect.
- Up-regulates pineal indoleamine metabolism.
- Reduces age-related decline in spatial memory in aged rats.
Full research protocol — dosing table
| Peptide | Dose | Frequency | Timing | Cycle length |
|---|---|---|---|---|
| Semax | 300–600 µg/day | Daily IN (split AM/midday) | Pre-cognitive task | 2–4 weeks |
| Selank | 400–800 µg/day | Daily IN (split AM/midday) | Before anxiogenic situations | 2–4 weeks |
| Pinealon | 20 mg | Daily SC | Evening | 10–14 days |
Weekly research timeline
| Peptide | Wk 1 | Wk 2 | Wk 3 | Wk 4 |
|---|---|---|---|---|
| Semax | 300 µg/day IN | 600 µg/day IN | 600 µg/day IN | 300 µg/day IN |
| Selank | 600 µg/day IN | 600 µg/day IN | 600 µg/day IN | 400 µg/day IN |
| Pinealon | 20 mg SC | 20 mg SC | — | — |
Routes: SC = subcutaneous · IM = intramuscular · IN = intranasal · Oral · Topical.
Safety profile & regulatory note
Where to source these research peptides
Each peptide in this stack has a dedicated research monograph on PeptideAuthority.co.uk and a research-grade SKU at PeptideBarn.co.uk. All compounds are sold strictly for in vitro research.